Publications by authors named "Michael Hafey"

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Membrane transporters in drug development and as determinants of precision medicine.
Aleksandra Galetin, Kim L R Brouwer, Donald Tweedie, Kenta Yoshida, Noora Sjöstedt, Michael J Hafey

Nat Rev Drug Discov· April 2024

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Transporters and Toxicity: Insights From the International Transporter Consortium Workshop 4.
Michael J Hafey, Lauren M Aleksunes, Christy C Bridges, Kenneth R Brouwer, Huan-Chieh Chien

Clin Pharmacol Ther· September 2022

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Islatravir Is Not Expected to Be a Victim or Perpetrator of Drug-Drug Interactions via Major Drug-Metabolizing Enzymes or Transporters.
Kelly Bleasby, Robert Houle, Michael Hafey, Meihong Lin, Jingjing Guo

Viruses· August 2021

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A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery.
Michael J Hafey, Robert Houle, Keith Q Tanis, Ian Knemeyer, Jackie Shang

Drug Metab Dispos· November 2020

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Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug-Induced Liver Toxicity.
Yutai Li, Raymond Evers, Michael J Hafey, Kyeongmi Cheon, Hong Duong

Toxicol Sci· July 2019

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Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective.
J Gerry Kenna, Kunal S Taskar, Christina Battista, David L Bourdet, Kim L R Brouwer, Michael J Hafey

Clin Pharmacol Ther· November 2018

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Structure-Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs.
Helen Y Chen, Christopher W Plummer, Dong Xiao, Harry R Chobanian, Duane DeMong, Michael J Hafey

ACS Med Chem Lett· July 2018

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Antibiotic-Induced Elevations of Plasma Bile Acids in Rats Independent of Bsep Inhibition.
Yutai Li, Michael J Hafey, Hong Duong, Raymond Evers, Kyeongmi Cheon

Toxicol Sci· May 2017

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Correction to Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
Izzat T Raheem, Abbas M Walji, Daniel Klein, John M Sanders, David A Powell, Michael J Hafey

J Med Chem· January 2016

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Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
Izzat T Raheem, Abbas M Walji, Daniel Klein, John M Sanders, David A Powell, Michael J Hafey

J Med Chem· October 2015

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Discovery of MK-8970: an acetal carbonate prodrug of raltegravir with enhanced colonic absorption.
Abbas M Walji, Rosa I Sanchez, Sophie-Dorothee Clas, Rebecca Nofsinger, Manuel de Lera Ruiz, Michael Hafey

ChemMedChem· February 2015

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Design of prodrugs to enhance colonic absorption by increasing lipophilicity and blocking ionization.
Rebecca Nofsinger, Sophie-Dorothee Clas, Rosa I Sanchez, Abbas Walji, Kimberly Manser, Michael Hafey

Pharmaceuticals (Basel)· February 2014

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Design, synthesis, and evaluation of prodrugs of ertapenem.
Sheo B Singh, Diane Rindgen, Prudence Bradley, Lovji Cama, Wanying Sun, Michael J Hafey

ACS Med Chem Lett· August 2013

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Nicotinic acids: liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy.
David A Powell, W Cameron Black, Kelly Bleasby, Chi-Chung Chan, Denis Deschenes, Michael J Hafey

Bioorg Med Chem Lett· December 2011

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Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents.
Jean-François Lévesque, Kelly Bleasby, Amandine Chefson, Austin Chen, Daniel Dubé, Michael Hafey

Bioorg Med Chem Lett· September 2011

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Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.
Renata M Oballa, Liette Belair, W Cameron Black, Kelly Bleasby, Chi Chung Chan, Michael J Hafey

J Med Chem· July 2011

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Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein.
Xiao-Yan Chu, Kelly Bleasby, Jocelyn Yabut, Xiaoxin Cai, Grace Hoyee Chan, Michael J Hafey

J Pharmacol Exp Ther· May 2007

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Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.
J I-Ju Leu, Patrick Dumont, Michael Hafey, Maureen E Murphy, Donna L George

Nat Cell Biol· May 2004

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