Publications by authors named "Nicolette John"

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Rapid and robust generation of cardiomyocyte-specific crispants in zebrafish using the cardiodeleter system.
Sean Keeley, Miriam Fernández-Lajarín, David Bergemann, Nicolette John, Lily Parrott

Cell Rep Methods· March 2025

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Optimization of methods for rapid and robust generation of cardiomyocyte-specific in zebrafish using the system.
Sean Keeley, Miriam Fernández-Lajarín, David Bergemann, Nicolette John, Lily Parrott

bioRxiv· September 2024

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Use of the bacterial reverse mutation assay to predict carcinogenicity of N-nitrosamines.
Alejandra Trejo-Martin, Joel P Bercu, Andrew Thresher, Rachael E Tennant, Robert F Thomas, John J Nicolette

Regul Toxicol Pharmacol· November 2022

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Exploring the molecular and functional cellular response to hydrazine via transcriptomics and DNA repair mutant cell lines.
Meredith E Crosby, Rita Ciurlionis, Timothy G Brayman, Alison Kondratiuk, John J Nicolette

Environ Mol Mutagen· August 2022

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An Evaluation of the Occupational Health Hazards of Peptide Couplers.
Jessica C Graham, Alejandra Trejo-Martin, Martyn L Chilton, Jakub Kostal, Joel Bercu, John Nicolette

Chem Res Toxicol· June 2022

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Deriving Compound-Specific Exposure Limits for Chemicals Used in Pharmaceutical Synthesis: Challenges in Expert Decision-Making Exemplified Through a Case Study-Based Workshop.
William C Drewe, Krista L Dobo, Zhanna Sobol, Joel P Bercu, Patricia Parris, John Nicolette

Int J Toxicol· January 2022

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Calculating qualified non-mutagenic impurity levels: Harmonization of approaches.
Jessica C Graham, Mark W Powley, Erika Udovic, Susanne Glowienke, John Nicolette

Regul Toxicol Pharmacol· November 2021

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Utility of a next-generation framework for assessment of genomic damage: A case study using the pharmaceutical drug candidate etoposide.
John Nicolette, Mirjam Luijten, Jennifer C Sasaki, Laura Custer, Michelle Embry, George Johnson

Environ Mol Mutagen· November 2021

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A cross-industry survey on photosafety evaluation of pharmaceuticals after implementation of ICH S10.
Daniel Bauer, Lorrene A Buckley, Laure Delafoy, Heidrun Ellinger-Ziegelbauer, Mick D Fellows, John Nicolette

Regul Toxicol Pharmacol· October 2021

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Harmonized 3Rs-based non-mutagenic impurity qualification study designs developed using the results of an IQ consortium survey.
Mayur S Mitra, Kaushik Datta, Richard Hutchinson, John J Nicolette, John C Pettersen

Regul Toxicol Pharmacol· June 2021

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Permitted daily exposure limits for noteworthy N-nitrosamines.
George E Johnson, Krista Dobo, Bhaskar Gollapudi, Jim Harvey, Julia Kenny, John Nicolette

Environ Mol Mutagen· June 2021

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In vitro and in vivo mammalian mutation assays support a nonmutagenic mechanism of carcinogenicity for hydrazine.
John Nicolette, Joel Murray, Paul Sonders, Alison Kondratiuk, Meredith Crosby

Environ Mol Mutagen· January 2021

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Management of pharmaceutical ICH M7 (Q)SAR predictions - The impact of model updates.
Catrin Hasselgren, Joel Bercu, Alex Cayley, Kevin Cross, Susanne Glowienke, John Nicolette

Regul Toxicol Pharmacol· December 2020

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Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
Emily J Faivre, Keith F McDaniel, Daniel H Albert, Srinivasa R Mantena, Joshua P Plotnik, John K Pratt, John J Nicolette

Nature· February 2020

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Principles and procedures for handling out-of-domain and indeterminate results as part of ICH M7 recommended (Q)SAR analyses.
Alexander Amberg, Roxanne V Andaya, Lennart T Anger, Chris Barber, Lisa Beilke, Candice Johnson, John Nicolette

Regul Toxicol Pharmacol· March 2019

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A comparison of transgenic rodent mutation and in vivo comet assay responses for 91 chemicals.
David Kirkland, Dan D Levy, Matthew J LeBaron, Marilyn J Aardema, Carol Beevers, George E Johnson, John J Nicolette

Mutat Res Genet Toxicol Environ Mutagen· March 2019

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A regenerative erythropoietic response does not increase the frequency of Pig-a mutant reticulocytes and erythrocytes in Sprague-Dawley rats.
John Nicolette, Joel Murray, Paul Sonders, Bruce Leroy

Environ Mol Mutagen· January 2018

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Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses.
Alexander Amberg, Lisa Beilke, Joel Bercu, Dave Bower, Alessandro Brigo, John Nicolette

Regul Toxicol Pharmacol· June 2016

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Peptide bond-forming reagents HOAt and HATU are not mutagenic in the bacterial reverse mutation test.
John Nicolette, Robin E Neft, Jessica Vanosdol, Joel Murray

Environ Mol Mutagen· April 2016

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Use of in silico systems and expert knowledge for structure-based assessment of potentially mutagenic impurities.
Andreas Sutter, Alexander Amberg, Scott Boyer, Alessandro Brigo, Joseph F Contrera, John Nicolette

Regul Toxicol Pharmacol· October 2013

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International Pig-a gene mutation assay trial: evaluation of transferability across 14 laboratories.
Stephen D Dertinger, Souk Phonethepswath, Pamela Weller, John Nicolette, Joel Murray

Environ Mol Mutagen· December 2011

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In vitro micronucleus screening of pharmaceutical candidates by flow cytometry in Chinese hamster V79 cells.
John Nicolette, Marilyn Diehl, Paul Sonders, Steve Bryce, Eric Blomme

Environ Mol Mutagen· June 2011

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Flow cytometric analysis of micronuclei in mammalian cell cultures: past, present and future.
Svetlana Avlasevich, Steven Bryce, Marlies De Boeck, Azeddine Elhajouji, Freddy Van Goethem, John Nicolette

Mutagenesis· January 2011

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High content flow cytometric micronucleus scoring method is applicable to attachment cell lines.
Steven M Bryce, Jing Shi, John Nicolette, Marilyn Diehl, Paul Sonders

Environ Mol Mutagen· April 2010

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