Publications by authors named "Rod Cupples"

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Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ*S-X) Interaction for Conformational Constraint.
Lewis D Pennington, Michael D Bartberger, Michael D Croghan, Kristin L Andrews, Kate S Ashton, Rod Cupples

J Med Chem· December 2015

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Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis.
Nuria A Tamayo, Mark H Norman, Michael D Bartberger, Fang-Tsao Hong, Yunxin Bo, Rod Cupples

J Med Chem· June 2015

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Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket.
Fang-Tsao Hong, Mark H Norman, Kate S Ashton, Michael D Bartberger, Jie Chen, Rod Cupples

J Med Chem· July 2014

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Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.
Nobuko Nishimura, Mark H Norman, Longbin Liu, Kevin C Yang, Kate S Ashton, Rod Cupples

J Med Chem· April 2014

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Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept.
Kate S Ashton, Kristin L Andrews, Marian C Bryan, Jie Chen, Kui Chen, Rod Cupples

J Med Chem· January 2014

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Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.
David J St Jean, Kate S Ashton, Michael D Bartberger, Jie Chen, Samer Chmait, Rod Cupples

J Med Chem· January 2014

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Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.
David J Lloyd, David J St Jean, Robert J M Kurzeja, Robert C Wahl, Klaus Michelsen, Rod Cupples

Nature· December 2013

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Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.
John L Buchanan, John R Newcomb, David P Carney, Stuart C Chaffee, Lilly Chai, Rod Cupples

Bioorg Med Chem Lett· April 2011

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Discovery of a potent, orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221).
Murielle M Véniant, Clarence Hale, Randall W Hungate, Kyung Gahm, Maurice G Emery, Rod Cupples

J Med Chem· June 2010

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Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model.
Christopher Fotsch, Michael D Bartberger, Eric A Bercot, Michelle Chen, Rod Cupples

J Med Chem· December 2008

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Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor.
Clarence Hale, Murielle Véniant, Zhulun Wang, Michelle Chen, Jocelyn McCormick, Rod Cupples

Chem Biol Drug Des· January 2008

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The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.
Chester Yuan, David J St Jean, Qingyian Liu, Lynn Cai, Aiwen Li, Rod Cupples

Bioorg Med Chem Lett· November 2007

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2-(S)-phenethylaminothiazolones as potent, orally efficacious inhibitors of 11beta-hydroxysteriod dehydrogenase type 1.
David J St Jean, Chester Yuan, Eric A Bercot, Rod Cupples, Michelle Chen

J Med Chem· February 2007

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