Publications by authors named "Stephanie Stout"

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Implementation of a strategy for identification and monitoring of clinical outcome measures in a department of pharmacy.
Mary-Haston Vest, Stephanie Stout, Kayla Waldron

Am J Health Syst Pharm· April 2022

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Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor.
David L McKinzie, Leonard L Winneroski, Steven J Green, Erik J Hembre, Jon A Erickson, Stephanie L Stout

J Med Chem· June 2021

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Defining Target Engagement Required for Efficacy at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt).
Charles W Lugar, Christian A Clarke, Richard Morphy, Helene Rudyk, Selma Sapmaz, Stephanie L Stout

J Med Chem· May 2021

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Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints.
Leonard L Winneroski, Jon A Erickson, Steven J Green, Jose E Lopez, Stephanie L Stout

Bioorg Med Chem· January 2020

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Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.
Saravanan Parthasarathy, Kenneth Henry, Huaxing Pei, Josh Clayton, Mark Rempala, Stephanie Stout

Bioorg Med Chem Lett· June 2018

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Merestinib (LY2801653) inhibits neurotrophic receptor kinase (NTRK) and suppresses growth of NTRK fusion bearing tumors.
Bruce W Konicek, Andrew R Capen, Kelly M Credille, Philip J Ebert, Beverly L Falcon, Stephanie L Stout

Oncotarget· March 2018

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Validation of Minimally-Invasive Sample Collection Methods for Measurement of Telomere Length.
Stephanie A Stout, Jue Lin, Natalie Hernandez, Elysia P Davis, Elizabeth Blackburn

Front Aging Neurosci· December 2017

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Exposure to unpredictable maternal sensory signals influences cognitive development across species.
Elysia Poggi Davis, Stephanie A Stout, Jenny Molet, Brian Vegetabile, Laura M Glynn

Proc Natl Acad Sci U S A· September 2017

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Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design.
Norman E Hughes, Thomas J Bleisch, Scott A Jones, Timothy I Richardson, Robert A Doti, Stephanie L Stout

Bioorg Med Chem Lett· July 2016

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Preparation and biological evaluation of conformationally constrained BACE1 inhibitors.
Leonard L Winneroski, Matthew A Schiffler, Jon A Erickson, Patrick C May, Scott A Monk, Stephanie L Stout

Bioorg Med Chem· July 2015

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ESR and X-ray Structure Investigations on the Binding and Mechanism of Inhibition of the Native State of Myeloperoxidase with Low Molecular Weight Fragments.
Balagopalakrishna Chavali, Thierry Masquelin, Mark J Nilges, David E Timm, Stephanie L Stout

Appl Magn Reson· May 2015

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Fetal programming of children's obesity risk.
Stephanie A Stout, Emma V Espel, Curt A Sandman, Laura M Glynn, Elysia Poggi Davis

Psychoneuroendocrinology· March 2015

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The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans.
Patrick C May, Brian A Willis, Stephen L Lowe, Robert A Dean, Scott A Monk, Stephanie L Stout

J Neurosci· January 2015

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Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
Timothy B Durham, Valentine J Klimkowski, Christopher J Rito, Jothirajah Marimuthu, James L Toth, Stephanie L Stout

J Med Chem· December 2014

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Early handling attenuates enhancement of glucocorticoid receptors in the prefrontal cortex in an animal model of post-traumatic stress disorder.
Sophie A George, Stephanie A Stout, Melissa Tan, Dayan Knox, Israel Liberzon

Biol Mood Anxiety Disord· December 2013

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LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models.
S Betty Yan, Victoria L Peek, Rose Ajamie, Sean G Buchanan, Jeremy R Graff, Stephanie L Stout

Invest New Drugs· August 2013

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Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor.
Patrick C May, Robert A Dean, Stephen L Lowe, Ferenc Martenyi, Scott M Sheehan, Stephanie L Stout

J Neurosci· November 2011

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Congenital adrenal hyperplasia: classification of studies employing psychological endpoints.
Stephanie A Stout, Margarita Litvak, Natashia M Robbins, David E Sandberg

Int J Pediatr Endocrinol· July 2011

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Requirements for catalysis in mammalian glycogenin.
Thomas D Hurley, Stephanie Stout, Emily Miner, Jing Zhou, Peter J Roach

J Biol Chem· June 2005

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