Publications by authors named "Gabriel M Simon"

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Identification of VVD-214/RO7589831, a Clinical-Stage, Covalent Allosteric Inhibitor of WRN Helicase for the Treatment of MSI-High Cancers.
Shota Kikuchi, Jason C Green, Don C Rogness, Betty Lam, Zachary A Owyang, Gabriel M Simon

J Med Chem· December 2025

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A covalent allosteric molecular glue suppresses NRF2-dependent cancer growth.
Nilotpal Roy, Tine Wyseure, I-Chung Lo, Justine Lu, Christie L Eissler, Gabriel M Simon

Cancer Discov· December 2025

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Covalent inhibitors of the PI3Kα RAS binding domain impair tumor growth driven by RAS and HER2.
Joseph E Klebba, Nilotpal Roy, Steffen M Bernard, Stephanie Grabow, Melissa A Hoffman, Gabriel M Simon

Science· November 2025

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Complexoform-restricted covalent TRMT112 ligands that allosterically agonize METTL5.
F Wieland Goetzke, Steffen M Bernard, Cheng-Wei Ju, Jonathan Pollock, Kristen E DeMeester, Gabriel M Simon

bioRxiv· May 2025

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Implications of frequent hitter E3 ligases in targeted protein degradation screens.
Xiaoyu Zhang, Gabriel M Simon, Benjamin F Cravatt

Nat Chem Biol· April 2025

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Covalent inhibitors of the RAS binding domain of PI3Kα impair tumor growth driven by RAS and HER2.
Joseph E Klebba, Nilotpal Roy, Steffen M Bernard, Stephanie Grabow, Melissa A Hoffman, Gabriel M Simon

bioRxiv· December 2024

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Multi-tiered chemical proteomic maps of tryptoline acrylamide-protein interactions in cancer cells.
Evert Njomen, Rachel E Hayward, Kristen E DeMeester, Daisuke Ogasawara, Melissa M Dix, Gabriel M Simon

Nat Chem· October 2024

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Author Correction: Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Kristen A Baltgalvis, Kelsey N Lamb, Kent T Symons, Chu-Chiao Wu, Melissa A Hoffman, Gabriel M Simon

Nature· July 2024

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Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Kristen A Baltgalvis, Kelsey N Lamb, Kent T Symons, Chu-Chiao Wu, Melissa A Hoffman, Gabriel M Simon

Nature· May 2024

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Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders.
Zhonglin Liu, Jarrett R Remsberg, Haoxin Li, Evert Njomen, Kristen E DeMeester, Gabriel M Simon

J Am Chem Soc· April 2024

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Assigning functionality to cysteines by base editing of cancer dependency genes.
Haoxin Li, Tiantai Ma, Jarrett R Remsberg, Sang Joon Won, Kristen E DeMeester, Gabriel M Simon

Nat Chem Biol· November 2023

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Proteomic discovery of chemical probes that perturb protein complexes in human cells.
Michael R Lazear, Jarrett R Remsberg, Martin G Jaeger, Katherine Rothamel, Hsuan-Lin Her, Simon J Hogg, Gabriel M Simon

Mol Cell· May 2023

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Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine.
Madeline E Kavanagh, Benjamin D Horning, Roli Khattri, Nilotpal Roy, Justine P Lu, Gabriel M Simon

Nat Chem Biol· December 2022

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Author Correction: Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine.
Madeline E Kavanagh, Benjamin D Horning, Roli Khattri, Nilotpal Roy, Justine P Lu, Gabriel M Simon

Nat Chem Biol· November 2022

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DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras.
Xiaoyu Zhang, Lena M Luukkonen, Christie L Eissler, Vincent M Crowley, Yu Yamashita, Gabriel M Simon

J Am Chem Soc· April 2021

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Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture.
Tomáš Vaisar, Jie H Hu, Nathan Airhart, Kate Fox, Jay Heinecke, Gabriel M Simon

Circ Res· September 2020

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An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells.
Ekaterina V Vinogradova, Xiaoyu Zhang, David Remillard, Daniel C Lazar, Radu M Suciu, Gabriel M Simon

Cell· August 2020

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ABHD4-dependent developmental anoikis safeguards the embryonic brain.
Zsófia I László, Zsolt Lele, Miklós Zöldi, Vivien Miczán, Fruzsina Mógor, Gabriel M Simon

Nat Commun· August 2020

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Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan.
Alice L Chen, Kenneth M Lum, Pablo Lara-Gonzalez, Daisuke Ogasawara, Armand B Cognetta, Gabriel M Simon

Nat Chem Biol· May 2019

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Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators.
Jason R Clapper, Cassandra L Henry, Micah J Niphakis, Anna M Knize, Aundrea R Coppola, Gabriel M Simon

J Pharmacol Exp Ther· December 2018

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Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders.
Justin S Cisar, Olivia D Weber, Jason R Clapper, Jacqueline L Blankman, Cassandra L Henry, Gabriel M Simon

J Med Chem· October 2018

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Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites.
Landon R Whitby, R Scott Obach, Gabriel M Simon, Matthew M Hayward, Benjamin F Cravatt

ACS Chem Biol· August 2017

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Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome.
Larisa V Lysenko, Jeesun Kim, Cassandra Henry, Anna Tyrtyshnaia, Rebecca A Kohnz, Gabriel M Simon

PLoS One· December 2015

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ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system.
Hyeon-Cheol Lee, Gabriel M Simon, Benjamin F Cravatt

Biochemistry· April 2015

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Bacteria from diverse habitats colonize and compete in the mouse gut.
Henning Seedorf, Nicholas W Griffin, Vanessa K Ridaura, Alejandro Reyes, Jiye Cheng, Gabriel M Simon

Cell· October 2014

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