Publications by authors named "George Hartman"

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Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action.
Kevin Wilhelmsen, Aditi Deshpande, Sarah Tronnes, Maitriyee Mahanta, Matthew Banicki, George Hartman

J Exp Med· November 2025

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The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening.
George Hartman, Paul Humphries, Robert Hughes, Andrew Ho, Rusty Montgomery

Bioorg Med Chem Lett· April 2024

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Diazepinone HBV capsid assembly modulators.
Scott D Kuduk, Lindsey G DeRatt, Bart Stoops, Paul Shaffer, Angela M Lam, George D Hartman

Bioorg Med Chem Lett· September 2022

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Oxadiazepinone HBV capsid assembly modulators.
Scott D Kuduk, Bart Stoops, Angela M Lam, Christine Espiritu, Robert Vogel, George D Hartman

Bioorg Med Chem Lett· November 2021

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Identification of a new class of HBV capsid assembly modulator.
Scott D Kuduk, Bart Stoops, Richard Alexander, Angela M Lam, Christine Espiritu, George D Hartman

Bioorg Med Chem Lett· May 2021

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450s nder striction (PURE) Screen Using HepaRG and Primary Human Hepatocytes for Discovery of Novel HBV Antivirals.
George D Hartman, Scott D Kuduk, Christine Espiritu, Angela M Lam

ACS Med Chem Lett· October 2020

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SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators.
Scott D Kuduk, Angela M Lam, Christine Espiritu, Robert Vogel, Vincent Lau, George D Hartman

Bioorg Med Chem Lett· August 2019

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Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection.
Man Fung Yuen, Edward J Gane, Dong Joon Kim, Frank Weilert, Henry Lik Yuen Chan, George Hartman

Gastroenterology· April 2019

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Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus.
Angela M Lam, Christine Espiritu, Robert Vogel, Suping Ren, Vincent Lau, George D Hartman

Antimicrob Agents Chemother· January 2019

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MK-7622: A First-in-Class M Positive Allosteric Modulator Development Candidate.
Douglas C Beshore, Christina N Di Marco, Ronald K Chang, Thomas J Greshock, Lei Ma, George D Hartman

ACS Med Chem Lett· July 2018

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Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection.
Klaus Klumpp, Takashi Shimada, Lena Allweiss, Tassilo Volz, Marc Lütgehetmann, George Hartman

Gastroenterology· February 2018

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Hepatitis B Virus Capsid Assembly Modulators, but Not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants.
Angela M Lam, Suping Ren, Christine Espiritu, Mollie Kelly, Vincent Lau, George D Hartman

Antimicrob Agents Chemother· August 2017

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Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics.
Scott E Wolkenberg, M Brad Nolt, Mark T Bilodeau, B Wesley Trotter, Peter J Manley, George D Hartman

Bioorg Med Chem Lett· February 2017

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High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein.
Klaus Klumpp, Angela M Lam, Christine Lukacs, Robert Vogel, Suping Ren, George Hartman

Proc Natl Acad Sci U S A· December 2015

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Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Anthony J Roecker, Thomas S Reger, M Christa Mattern, Swati P Mercer, Jeffrey M Bergman, George D Hartman

Bioorg Med Chem Lett· October 2014

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Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase.
Antonella Converso, Timothy Hartingh, Mark E Fraley, Robert M Garbaccio, George D Hartman

Bioorg Med Chem Lett· June 2014

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Discovery of naphthyl-fused 5-membered lactams as a new class of m1 positive allosteric modulators.
Zhi-Qiang Yang, Youheng Shu, Lei Ma, Marion Wittmann, William J Ray, George D Hartman

ACS Med Chem Lett· May 2014

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Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M(1) positive allosteric modulators.
Scott D Kuduk, Christina N Di Marco, Jonathan R Saffold, William J Ray, Lei Ma, George D Hartman

Bioorg Med Chem Lett· March 2014

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Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Anthony J Roecker, Swati P Mercer, John D Schreier, Christopher D Cox, Mark E Fraley, George D Hartman

ChemMedChem· February 2014

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Benzimidazole CB2 agonists: design, synthesis and SAR.
Kausik K Nanda, Darrell A Henze, Kimberly Della Penna, Reshma Desai, Michael Leitl, George D Hartman

Bioorg Med Chem Lett· February 2014

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Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs).
Swati P Mercer, Anthony J Roecker, Susan Garson, Duane R Reiss, C Meacham Harrell, George D Hartman

Bioorg Med Chem Lett· December 2013

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Identification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators.
Scott D Kuduk, Ronald K Chang, Thomas J Greshock, William J Ray, Lei Ma, George D Hartman

ACS Med Chem Lett· December 2012

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Pyridyl aminothiazoles as potent Chk1 inhibitors: optimization of cellular activity.
Vadim Y Dudkin, Cheng Wang, Kenneth L Arrington, Mark E Fraley, George D Hartman

Bioorg Med Chem Lett· April 2012

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Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates.
Vadim Y Dudkin, Keith Rickert, Constantine Kreatsoulas, Cheng Wang, Kenneth L Arrington, George D Hartman

Bioorg Med Chem Lett· April 2012

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Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties.
Paul J Coleman, John D Schreier, Christopher D Cox, Michael J Breslin, David B Whitman, George D Hartman

ChemMedChem· March 2012

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