Publications by authors named "Heidi Greulich"

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Sevabertinib, a Reversible HER2 Inhibitor with Activity in Lung Cancer.
Franziska Siegel, Stephan Siegel, Kristýna Kotýnková, Gizem Karsli Uzunbas, Daniel Korr, Heidi Greulich

Cancer Discov· October 2025

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Discovery of BAY 2666605, a Molecular Glue for PDE3A and SLFN12.
Timothy A Lewis, Manuel Ellermann, Charlotte Kopitz, Martin Lange, Luc de Waal, Heidi Greulich

ACS Med Chem Lett· October 2024

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Correction: Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants.
Heidi Greulich, Tzu-Hsiu Chen, Whei Feng, Pasi A Jänne, James V Alvarez

PLoS Med· September 2024

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Velcrin molecular glues induce apoptosis in glioblastomas with high and expression.
Elisa Aquilanti, Silvia Goldoni, Andrew Baker, Kristyna Kotynkova, Sawyer Andersen, Heidi Greulich

Neurooncol Adv· July 2024

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Velcrin compounds activate the SLFN12 tRNase to induce tomoptosis.
Heidi Greulich

Cell Chem Biol· June 2024

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Velcrin-induced selective cleavage of tRNA(TAA) by SLFN12 causes cancer cell death.
Sooncheol Lee, Stephanie Hoyt, Xiaoyun Wu, Colin Garvie, Joseph McGaunn, Heidi Greulich

Nat Chem Biol· March 2023

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A complex puzzle: Regulation of SLFN12 RNase activity by phosphorylation.
Heidi Greulich

Cell Chem Biol· June 2022

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Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Colin W Garvie, Xiaoyun Wu, Malvina Papanastasiou, Sooncheol Lee, James Fuller, Heidi Greulich

Nat Commun· July 2021

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Correction: Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12.
Xiaoyun Wu, Gavin R Schnitzler, Galen F Gao, Brett Diamond, Andrew R Baker, Heidi Greulich

J Biol Chem· November 2020

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Colorectal adenocarcinoma-derived EGFR mutants are oncogenic and sensitive to EGFR-targeted monoclonal antibodies, cetuximab and panitumumab.
Nayoung Kim, Daseul Cho, Hyunjin Kim, Sujin Kim, Young-Je Cha, Heidi Greulich

Int J Cancer· April 2020

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Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12.
Xiaoyun Wu, Gavin R Schnitzler, Galen F Gao, Brett Diamond, Andrew R Baker, Heidi Greulich

J Biol Chem· March 2020

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Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling.
Steven M Corsello, Rohith T Nagari, Ryan D Spangler, Jordan Rossen, Mustafa Kocak, Heidi Greulich

Nat Cancer· February 2020

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Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing.
Timothy A Lewis, Luc de Waal, Xiaoyun Wu, Willmen Youngsaye, Antje Wengner, Heidi Greulich

ACS Med Chem Lett· November 2019

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Genetic clues can be used to predict whether early-stage cancer will form an invasive tumour.
Heidi Greulich, Andrew D Cherniack

Nature· February 2019

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Characterizing genomic alterations in cancer by complementary functional associations.
Jong Wook Kim, Olga B Botvinnik, Omar Abudayyeh, Chet Birger, Joseph Rosenbluh, Heidi Greulich

Nat Biotechnol· May 2016

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Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.
Luc de Waal, Timothy A Lewis, Matthew G Rees, Aviad Tsherniak, Xiaoyun Wu, Heidi Greulich

Nat Chem Biol· February 2016

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Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab.
Jeonghee Cho, Adam J Bass, Michael S Lawrence, Kristian Cibulskis, Ahye Cho, Heidi Greulich

Mol Cancer· June 2014

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Oncogenic and sorafenib-sensitive ARAF mutations in lung adenocarcinoma.
Marcin Imielinski, Heidi Greulich, Bethany Kaplan, Luiz Araujo, Joseph Amann

J Clin Invest· April 2014

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Landscape of genomic alterations in cervical carcinomas.
Akinyemi I Ojesina, Lee Lichtenstein, Samuel S Freeman, Chandra Sekhar Pedamallu, Ivan Imaz-Rosshandler, Heidi Greulich

Nature· February 2014

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Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerization.
Jeonghee Cho, Liang Chen, Naveen Sangji, Takafumi Okabe, Kimio Yonesaka, Heidi Greulich

Cancer Res· November 2013

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Activating Mutations in ERBB2 and Their Impact on Diagnostics and Treatment.
Grit S Herter-Sprie, Heidi Greulich, Kwok-Kin Wong

Front Oncol· May 2013

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Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.
Heidi Greulich, Bethany Kaplan, Philipp Mertins, Tzu-Hsiu Chen, Kumiko E Tanaka

Proc Natl Acad Sci U S A· September 2012

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Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing.
Marcin Imielinski, Alice H Berger, Peter S Hammerman, Bryan Hernandez, Trevor J Pugh, Heidi Greulich

Cell· September 2012

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Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.
Trevor J Pugh, Shyamal Dilhan Weeraratne, Tenley C Archer, Daniel A Pomeranz Krummel, Daniel Auclair, Heidi Greulich

Nature· August 2012

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