Publications by authors named "Joseph Leone"

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Synthesis of a Complex and Highly Potent PCSK9 Inhibitor.
Jeffrey T Kuethe, Joshua Lee, David Thaisrivongs, Nobuyoshi Yasuda, Scott R Pollack, Joseph Leone

Org Lett· July 2023

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NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods.
Maria Lorna A De Leoz, David L Duewer, Adam Fung, Lily Liu, Hoi Kei Yau, Joseph W Leone

Mol Cell Proteomics· January 2020

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FusorSV: an algorithm for optimally combining data from multiple structural variation detection methods.
Timothy Becker, Wan-Ping Lee, Joseph Leone, Qihui Zhu, Chengsheng Zhang

Genome Biol· March 2018

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Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain.
Harry R Chobanian, Yan Guo, Ping Liu, Marc D Chioda, Selena Fung, Joseph F Leone

ACS Med Chem Lett· June 2014

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Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase.
Ping Liu, Terence G Hamill, Marc Chioda, Harry Chobanian, Selena Fung, Joseph F Leone

ACS Med Chem Lett· June 2013

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Evidence for cyclic diguanylate as a vaccine adjuvant with novel immunostimulatory activities.
Peter M Gray, Gail Forrest, Thomas Wisniewski, Gene Porter, Daniel C Freed, Joseph Leone

Cell Immunol· January 2013

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Removal of N-terminal blocking groups from proteins.
Joseph W Leone, Brian Hampton, Elizabeth Fowler, Mary Moyer, Radha G Krishna

Curr Protoc Protein Sci· February 2011

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Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.
Jill E Chrencik, Akshay Patny, Iris K Leung, Brian Korniski, Thomas L Emmons, Joseph W Leone

J Mol Biol· July 2010

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Expression, purification, and characterization of TYK-2 kinase domain, a member of the Janus kinase family.
Brian Korniski, Arthur J Wittwer, Thomas L Emmons, Troii Hall, Stacy Brown, Joseph W Leone

Biochem Biophys Res Commun· May 2010

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Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain.
Troii Hall, Thomas L Emmons, Jill E Chrencik, Jennifer A Gormley, Robin A Weinberg, Joseph W Leone

Protein Expr Purif· January 2010

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Cyclic phosphoramidates as prodrugs of 2'-C-methylcytidine.
Malte Meppen, Barbara Pacini, Renzo Bazzo, Uwe Koch, Joseph F Leone

Eur J Med Chem· September 2009

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Multiple strategies for the preparation of a sulfur-35 labeled NPC1L1 radioligand.
Joseph P Simeone, Matthew P Braun, Joseph F Leone, Peter Lin, Robert J DeVita

Bioorg Med Chem Lett· September 2009

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ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala(271).
Marc D Zack, Anne-Marie Malfait, Adam P Skepner, Matthew P Yates, David W Griggs, Joseph W Leone

Arthritis Rheum· September 2009

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Phosphoramidate prodrugs of 2'-C-methylcytidine for therapy of hepatitis C virus infection.
Cristina Gardelli, Barbara Attenni, Monica Donghi, Malte Meppen, Barbara Pacini, Joseph F Leone

J Med Chem· September 2009

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Autoactivation of human ADAM8: a novel pre-processing step is required for catalytic activity.
Troii Hall, Joseph W Leone, Joseph F Wiese, David W Griggs, Lyle E Pegg

Biosci Rep· August 2009

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Purification and characterization of recombinant human soluble guanylate cyclase produced from baculovirus-infected insect cells.
Thomas L Emmons, Karl J Mathis, Mary E Shuck, Beverly A Reitz, Daniel F Curran, Joseph W Leone

Protein Expr Purif· June 2009

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HILIC LC-MS for the determination of 2'-C-methyl-cytidine-triphosphate in rat liver.
Vincenzo Pucci, Claudio Giuliano, Rena Zhang, Kenneth Alan Koeplinger, Joseph F Leone

J Sep Sci· May 2009

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Synthesis and evaluation of novel phosphoramidate prodrugs of 2'-methyl cytidine as inhibitors of hepatitis C virus NS5B polymerase.
Monica Donghi, Barbara Attenni, Cristina Gardelli, Annalise Di Marco, Fabrizio Fiore, Joseph F Leone

Bioorg Med Chem Lett· March 2009

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Madin-Darby canine kidney II cells: a pharmacologically validated system for NPC1L1-mediated cholesterol uptake.
Adam B Weinglass, Martin G Köhler, Emmanuel O Nketiah, Jessica Liu, William Schmalhofer, Joseph Leone

Mol Pharmacol· April 2008

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High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2).
Huey-Sheng Shieh, Karl J Mathis, Jennifer M Williams, Robert L Hills, Joe F Wiese, Joseph W Leone

J Biol Chem· January 2008

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Synthesis and HCV inhibitory properties of 9-deaza- and 7,9-dideaza-7-oxa-2'-C-methyladenosine.
Gabor Butora, David B Olsen, Steven S Carroll, Daniel R McMasters, Christoph Schmitt, Joseph F Leone

Bioorg Med Chem· August 2007

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Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate.
Robert Hills, Richard Mazzarella, Kam Fok, Min Liu, Olga Nemirovskiy, Joseph Leone

J Biol Chem· April 2007

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Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors.
Jinyou Xu, Lan Wei, Robert J Mathvink, Scott D Edmondson, George J Eiermann, Joseph F Leone

Bioorg Med Chem Lett· October 2006

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(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Scott D Edmondson, Anthony Mastracchio, Robert J Mathvink, Jiafang He, Bart Harper, Joseph F Leone

J Med Chem· June 2006

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Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors.
Jinyou Xu, Lan Wei, Robert Mathvink, Scott D Edmondson, Anthony Mastracchio, Joseph F Leone

Bioorg Med Chem Lett· March 2006

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