Publications by authors named "Kristin Riching"

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Evaluation of Cereblon-Directing Warheads for the Development of Orally Bioavailable PROTACs.
Marisa Actis, Joel Cresser-Brown, Elizabeth A Caine, Martin Steger, Anup Aggarwal, Kristin M Riching

J Med Chem· February 2025

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Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation.
Giuseppe Quarto, Andrea Li Greci, Martin Bizet, Audrey Penning, Irina Primac, Kristin M Riching

Cell· February 2025

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Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera.
Adam G Bond, Miquel Muñoz I Ordoño, Celia M Bisbach, Conner Craigon, Nikolai Makukhin, Kristin M Riching

J Am Chem Soc· December 2024

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Structure-Activity Relationship of Potent, Selective, and Orally Bioavailable Molecular Glue Degraders of CK1α.
Gisele Nishiguchi, Elizabeth A Caine, Kevin McGowan, Zhe Shi, Anup Aggarwal, Kristin M Riching

ACS Med Chem Lett· October 2024

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Lysineless HiBiT and NanoLuc Tagging Systems as Alternative Tools for Monitoring Targeted Protein Degradation.
Hanfeng Lin, Kristin Riching, May Poh Lai, Dong Lu, Ran Cheng

ACS Med Chem Lett· August 2024

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Lysineless HiBiT and NanoLuc Tagging Systems as Alternative Tools Monitoring Targeted Protein Degradation.
Hanfeng Lin, Kristin Riching, May Poh Lai, Dong Lu, Ran Cheng

bioRxiv· May 2024

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Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines.
Gisele Nishiguchi, Lauren G Mascibroda, Sarah M Young, Elizabeth A Caine, Sherif Abdelhamed, Kristin M Riching

Nat Commun· January 2024

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SRSF2 plays an unexpected role as reader of mC on mRNA, linking epitranscriptomics to cancer.
Hai-Li Ma, Martin Bizet, Christelle Soares Da Costa, Frédéric Murisier, Eric James de Bony, Kristin M Riching

Mol Cell· December 2023

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Development of an intracellular quantitative assay to measure compound binding kinetics.
Charles S Lay, Daniel A Thomas, John P Evans, Matthew Campbell, Kristopher McCombe, Kristin Riching

Cell Chem Biol· December 2023

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Monitoring PROTAC interactions in biochemical assays using Lumit immunoassays.
Ellen K Crummy, Elizabeth A Caine, Dareen Mikheil, Cesear Corona, Kristin M Riching

Methods Enzymol· February 2023

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Kinetic Detection of E3:PROTAC:Target Ternary Complexes Using NanoBRET Technology in Live Cells.
Sarah D Mahan, Kristin M Riching, Marjeta Urh, Danette L Daniels

Methods Mol Biol· November 2022

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The importance of cellular degradation kinetics for understanding mechanisms in targeted protein degradation.
Kristin M Riching, Elizabeth A Caine, Marjeta Urh, Danette L Daniels

Chem Soc Rev· July 2022

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Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs.
Nan Bai, Kristin M Riching, Aman Makaju, Hao Wu, Timothy M Acker

J Biol Chem· April 2022

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Development of an intracellular quantitative assay to measure compound binding kinetics.
Charles S Lay, Daniel A Thomas, John P Evans, Matthew Campbell, Kristopher McCombe, Kristin Riching

Cell Chem Biol· February 2022

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Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity.
Satomi Imaide, Kristin M Riching, Nikolai Makukhin, Vesna Vetma, Claire Whitworth

Nat Chem Biol· November 2021

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Discovery and resistance mechanism of a selective CDK12 degrader.
Baishan Jiang, Yang Gao, Jianwei Che, Wenchao Lu, Ines H Kaltheuner, Kristin M Riching

Nat Chem Biol· June 2021

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CDK Family PROTAC Profiling Reveals Distinct Kinetic Responses and Cell Cycle-Dependent Degradation of CDK2.
Kristin M Riching, Marie K Schwinn, James D Vasta, Matthew B Robers, Thomas Machleidt

SLAS Discov· April 2021

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Targeted Protein Degradation Phenotypic Studies Using HaloTag CRISPR/Cas9 Endogenous Tagging Coupled with HaloPROTAC3.
Elizabeth A Caine, Sarah D Mahan, Rebecca L Johnson, Amanda N Nieman, Ngan Lam, Kristin M Riching

Curr Protoc Pharmacol· December 2020

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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds using HiBiT CRISPR Cell Lines.
Kristin M Riching, Sarah D Mahan, Marjeta Urh, Danette L Daniels

J Vis Exp· November 2020

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Monitoring and deciphering protein degradation pathways inside cells.
Danette L Daniels, Kristin M Riching, Marjeta Urh

Drug Discov Today Technol· April 2019

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Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7.
Vittoria Zoppi, Scott J Hughes, Chiara Maniaci, Andrea Testa, Teresa Gmaschitz, Kristin M Riching

J Med Chem· January 2019

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Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action.
Kristin M Riching, Sarah Mahan, Cesear R Corona, Mark McDougall, James D Vasta

ACS Chem Biol· September 2018

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Real-time analysis of the binding of fluorescent VEGFa to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes.
Laura E Kilpatrick, Rachel Friedman-Ohana, Diana C Alcobia, Kristin Riching, Chloe J Peach

Biochem Pharmacol· July 2017

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Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo.
Brian Burkel, Brett A Morris, Suzanne M Ponik, Kristin M Riching, Kevin W Eliceiri

J Vis Exp· May 2016

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Rho family GTPases: making it to the third dimension.
Kristin M Riching, Patricia J Keely

Int J Biochem Cell Biol· February 2015

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