Publications by authors named "Marie Claude Mathieu"

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The Discovery of RP-2119: A Potent, Selective, and Orally Bioavailable Polθ ATPase Inhibitor.
Philippe Mochirian, Robert Papp, Marie-Claude Mathieu, Gino B Ferraro, Evelyne Dietrich, Yann Mathieu

J Med Chem· September 2025

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Identification of , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ.
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Marie-Claude Mathieu

J Med Chem· October 2022

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Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.
Alejandro Álvarez-Quilón, Jessica L Wojtaszek, Marie-Claude Mathieu, Tejas Patel, C Denise Appel

Mol Cell· June 2020

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Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene.
Jimmy Fourtounis, I-Ming Wang, Marie-Claude Mathieu, David Claveau, Tenneille Loo

Respir Res· October 2012

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Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor.
Jason D Burch, Julie Farand, John Colucci, Claudio Sturino, Yves Ducharme, Marie-Claude Mathieu

Bioorg Med Chem Lett· February 2011

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A novel series of potent and selective EP(4) receptor ligands: facile modulation of agonism and antagonism.
Michael J Boyd, Carl Berthelette, Jean-François Chiasson, Patsy Clark, John Colucci, Marie-Claude Mathieu

Bioorg Med Chem Lett· January 2011

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The identification of substituted benzothiophene derivatives as PGE(2) subtype 4 receptor antagonists: From acid to non-acid.
Lianhai Li, Marie-Claude Mathieu, Danielle Denis, Alex G Therien, Zhaoyin Wang

Bioorg Med Chem Lett· January 2011

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Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain.
John Colucci, Michael Boyd, Carl Berthelette, Jean-Francois Chiasson, Zhaoyin Wang, Marie-Claude Mathieu

Bioorg Med Chem Lett· June 2010

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The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.
Marc Blouin, Yongxin Han, Jason Burch, Julie Farand, Christophe Mellon, Marie-Claude Mathieu

J Med Chem· March 2010

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Discovery of potent and selective DP1 receptor antagonists in the azaindole series.
Yves Leblanc, Patrick Roy, Claude Dufresne, Nicolas Lachance, Zhaoyin Wang, Marie-Claude Mathieu

Bioorg Med Chem Lett· April 2009

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Adenovirus IL-13-induced airway disease in mice: a corticosteroid-resistant model of severe asthma.
Alex G Therien, Virginie Bernier, Sean Weicker, Paul Tawa, Jean-Pierre Falgueyret, Marie-Claude Mathieu

Am J Respir Cell Mol Biol· July 2008

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Mutual antagonistic relationship between prostaglandin E(2) and IFN-gamma: Implications for rheumatoid arthritis.
Marie-Claude Mathieu, Simon Lord-Dufour, Virginie Bernier, Yves Boie, Jason D Burch

Eur J Immunol· July 2008

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MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis.
Patsy Clark, Steven E Rowland, Danielle Denis, Marie-Claude Mathieu, Rino Stocco

J Pharmacol Exp Ther· May 2008

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Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold.
Christian Beaulieu, Daniel Guay, Zhaoyin Wang, Yves Leblanc, Patrick Roy, Marie-Claude Mathieu

Bioorg Med Chem Lett· April 2008

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Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP(4) receptor.
Jason D Burch, Michel Belley, Réjean Fortin, Denis Deschênes, Mario Girard, Marie-Claude Mathieu

Bioorg Med Chem Lett· March 2008

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Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).
Claudio F Sturino, Gary O'Neill, Nicolas Lachance, Michael Boyd, Carl Berthelette, Marie-Claude Mathieu

J Med Chem· February 2007

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Prostacyclin antagonism reduces pain and inflammation in rodent models of hyperalgesia and chronic arthritis.
Anne-Marie Pulichino, Steve Rowland, Tom Wu, Patsy Clark, Daigen Xu, Marie-Claude Mathieu

J Pharmacol Exp Ther· December 2006

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Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I.
Virginie Bernier, Rino Stocco, Michael J Bogusky, Joseph G Joyce, Christine Parachoniak, Marie-Claude Mathieu

J Biol Chem· August 2006

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Identification of an indole series of prostaglandin D2 receptor antagonists.
Claudio F Sturino, Nicolas Lachance, Michael Boyd, Carl Berthelette, Marc Labelle, Marie-Claude Mathieu

Bioorg Med Chem Lett· June 2006

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The C3a receptor antagonist SB 290157 has agonist activity.
Marie-Claude Mathieu, Nicole Sawyer, Gillian M Greig, Martine Hamel, Stacia Kargman

Immunol Lett· September 2005

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Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.
Xavier Billot, Anne Chateauneuf, Nathalie Chauret, Danielle Denis, Gillian Greig, Marie Claude Mathieu

Bioorg Med Chem Lett· March 2003

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