Publications by authors named "Roman Sakowicz"

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Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis.
Eda Canales, Winston Tse, Scott D Schroeder, Chien-Hung Chou, Qi Liu, Roman Sakowicz

J Med Chem· October 2025

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Species-Specific Urothelial Toxicity With an Anti-HIV Noncatalytic Site Integrase Inhibitor (NCINI) Is Related to Unusual pH-Dependent Physicochemical Changes.
Ruth A Roberts, Richard A Campbell, Phumzile Sikakana, Claire Sadler, Mark Osier, Roman Sakowicz

Toxicol Sci· August 2021

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Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells.
Ruidong Li, Albert Liclican, Yili Xu, Jared Pitts, Congrong Niu, Roman Sakowicz

Antimicrob Agents Chemother· August 2021

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Off-Target Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent.
Yili Xu, Ona Barauskas, Cynthia Kim, Darius Babusis, Eisuke Murakami, Roman Sakowicz

Antimicrob Agents Chemother· January 2021

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Clinical targeting of HIV capsid protein with a long-acting small molecule.
John O Link, Martin S Rhee, Winston C Tse, Jim Zheng, John R Somoza, Roman Sakowicz

Nature· August 2020

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Biochemical characterization of tirabrutinib and other irreversible inhibitors of Bruton's tyrosine kinase reveals differences in on - and off - target inhibition.
Albert Liclican, Loredana Serafini, Weimei Xing, Gregg Czerwieniec, Bart Steiner, Roman Sakowicz

Biochim Biophys Acta Gen Subj· April 2020

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The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca/CaM.
Melanie H Wong, Alexandra B Samal, Mike Lee, Jiri Vlach, Nikolai Novikov, Roman Sakowicz

J Mol Biol· March 2019

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Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors.
Weimei Xing, Ona Barauskas, Thorsten Kirschberg, Anita Niedziela-Majka, Michael Clarke, Roman Sakowicz

PLoS One· October 2017

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Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs.
Ona Barauskas, Weimei Xing, Esmeralda Aguayo, Madeleine Willkom, Annapurna Sapre, Roman Sakowicz

PLoS One· October 2017

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Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9.
Todd C Appleby, Andrew E Greenstein, Magdeleine Hung, Albert Liclican, Maile Velasquez, Roman Sakowicz

J Biol Chem· April 2017

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Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus.
Joy Y Feng, Yili Xu, Ona Barauskas, Jason K Perry, Shekeba Ahmadyar, Roman Sakowicz

Antimicrob Agents Chemother· February 2016

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Direct binding of ledipasvir to HCV NS5A: mechanism of resistance to an HCV antiviral agent.
Hyock Joo Kwon, Weimei Xing, Katie Chan, Anita Niedziela-Majka, Katherine M Brendza, Roman Sakowicz

PLoS One· December 2015

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GS-5806 inhibits pre- to postfusion conformational changes of the respiratory syncytial virus fusion protein.
Dharmaraj Samuel, Weimei Xing, Anita Niedziela-Majka, Jinny S Wong, Magdeleine Hung, Roman Sakowicz

Antimicrob Agents Chemother· November 2015

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High-throughput screening of formulations to optimize the thermal stability of a therapeutic monoclonal antibody.
Anita Niedziela-Majka, Elaine Kan, Perry Weissburg, Upasana Mehra, Scott Sellers, Roman Sakowicz

J Biomol Screen· April 2015

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Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly.
Latesh Lad, Sheila Clancy, David Koditek, Melanie H Wong, Debi Jin, Roman Sakowicz

Biochemistry· April 2015

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Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors.
Sarah E Boyce, Neeraj Tirunagari, Anita Niedziela-Majka, Jason Perry, Melanie Wong, Roman Sakowicz

PLoS One· September 2014

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Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells.
Mini Balakrishnan, Stephen R Yant, Luong Tsai, Christopher O'Sullivan, Rujuta A Bam, Roman Sakowicz

PLoS One· June 2014

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Large-scale functional purification of recombinant HIV-1 capsid.
Magdeleine Hung, Anita Niedziela-Majka, Debi Jin, Melanie Wong, Stephanie Leavitt, Roman Sakowicz

PLoS One· December 2013

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The HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function.
Christy M Hebner, Bin Han, Katherine M Brendza, Michelle Nash, Maisoun Sulfab, Roman Sakowicz

PLoS One· December 2012

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Lipid-sensing high-throughput ApoA-I assays.
Anita Niedziela-Majka, Latesh Lad, Jeffrey W Chisholm, Leanna Lagpacan, Karen Schwartz, Roman Sakowicz

J Biomol Screen· September 2012

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New class of HIV-1 integrase (IN) inhibitors with a dual mode of action.
Manuel Tsiang, Gregg S Jones, Anita Niedziela-Majka, Elaine Kan, Eric B Lansdon, Roman Sakowicz

J Biol Chem· June 2012

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A trimer of dimers is the basic building block for human immunodeficiency virus-1 capsid assembly.
Manuel Tsiang, Anita Niedziela-Majka, Magdeleine Hung, Debi Jin, Eric Hu, Roman Sakowicz

Biochemistry· June 2012

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Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation.
Manuel Tsiang, Gregg S Jones, Magdeleine Hung, Dharmaraj Samuel, Nikolai Novikov, Roman Sakowicz

Biochemistry· March 2011

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Cardiac myosin activation: a potential therapeutic approach for systolic heart failure.
Fady I Malik, James J Hartman, Kathleen A Elias, Bradley P Morgan, Hector Rodriguez, Roman Sakowicz

Science· March 2011

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Insight into the molecular mechanism of the multitasking kinesin-8 motor.
Carsten Peters, Katjuša Brejc, Lisa Belmont, Andrew J Bodey, Yan Lee, Roman Sakowicz

EMBO J· October 2010

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