Publications by authors named "Travis Wager"

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Harnessing Preclinical Data as a Predictive Tool for Human Brain Tissue Targeting.
Nandini C Patel, Bo Feng, Xinjun Hou, Mark A West, Patrick E Trapa, Travis T Wager

ACS Chem Neurosci· March 2021

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Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE.
Uthpala Seneviratne, Zhen Huang, Christopher W Am Ende, Todd W Butler, Leah Cleary, Travis T Wager

Cell Chem Biol· February 2021

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A perspective on the physicochemical and biopharmaceutic properties of marketed antiseizure drugs-From phenobarbital to cenobamate and beyond.
Reem Odi, David Bibi, Travis Wager, Meir Bialer

Epilepsia· August 2020

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Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing.
Jonathan L Chen, Peiyuan Zhang, Masahito Abe, Haruo Aikawa, Liying Zhang, Travis T Wager

J Am Chem Soc· May 2020

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Validation of Human MDR1-MDCK and BCRP-MDCK Cell Lines to Improve the Prediction of Brain Penetration.
Bo Feng, Mark West, Nandini C Patel, Travis Wager, Xinjun Hou

J Pharm Sci· July 2019

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Systems approach reveals photosensitivity and PER2 level as determinants of clock-modulator efficacy.
Dae Wook Kim, Cheng Chang, Xian Chen, Angela C Doran, Francois Gaudreault, Travis Wager

Mol Syst Biol· July 2019

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In Vitro-In Vivo Extrapolation of Key Transporter Activity at the Blood-Brain Barrier.
Patrick E Trapa, Matthew D Troutman, Thomas Y Lau, Travis T Wager, Tristan S Maurer

Drug Metab Dispos· April 2019

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Author Correction: Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs.
Noelia Ferruz, Stefan Doerr, Michelle A Vanase-Frawley, Yaozhong Zou, Xiaomin Chen, Travis T Wager

Sci Rep· April 2019

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Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189.
Antonia F Stepan, Tuan P Tran, Christopher J Helal, Maria S Brown, Cheng Chang, Travis T Wager

ACS Med Chem Lett· February 2018

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Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs.
Noelia Ferruz, Stefan Doerr, Michelle A Vanase-Frawley, Yaozhong Zou, Xiaomin Chen, Travis T Wager

Sci Rep· January 2018

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Identification and Profiling of a Selective and Brain Penetrant Radioligand for in Vivo Target Occupancy Measurement of Casein Kinase 1 (CK1) Inhibitors.
Travis T Wager, Paul Galatsis, Ramalakshmi Y Chandrasekaran, Todd W Butler, Jianke Li

ACS Chem Neurosci· September 2017

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Dopamine D3/D2 Receptor Antagonist PF-4363467 Attenuates Opioid Drug-Seeking Behavior without Concomitant D2 Side Effects.
Travis T Wager, Thomas Chappie, David Horton, Ramalakshmi Y Chandrasekaran, Brian Samas

ACS Chem Neurosci· January 2017

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Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity.
Peter S Cunningham, Siobhán A Ahern, Laura C Smith, Carla S da Silva Santos, Travis T Wager

Sci Rep· July 2016

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Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery.
Travis T Wager, Xinjun Hou, Patrick R Verhoest, Anabella Villalobos

ACS Chem Neurosci· June 2016

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Quantitative Assessment of the Impact of Fluorine Substitution on P-Glycoprotein (P-gp) Mediated Efflux, Permeability, Lipophilicity, and Metabolic Stability.
Martin Pettersson, Xinjun Hou, Max Kuhn, Travis T Wager, Gregory W Kauffman

J Med Chem· June 2016

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Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor.
Jaclyn L Henderson, Bethany L Kormos, Matthew M Hayward, Karen J Coffman, Jayasankar Jasti, Travis T Wager

J Med Chem· January 2015

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Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior.
Travis T Wager, Ramalakshmi Y Chandrasekaran, Jenifer Bradley, David Rubitski, Helen Berke

ACS Chem Neurosci· December 2014

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Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold.
Paul Galatsis, Jaclyn L Henderson, Bethany L Kormos, Seungil Han, Ravi G Kurumbail, Travis T Wager

Bioorg Med Chem Lett· September 2014

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A novel mechanism controlling resetting speed of the circadian clock to environmental stimuli.
Violetta Pilorz, Peter S Cunningham, Anthony Jackson, Alexander C West, Travis T Wager

Curr Biol· March 2014

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Improving the odds of success in drug discovery: choosing the best compounds for in vivo toxicology studies.
Travis T Wager, Bethany L Kormos, Joseph T Brady, Yvonne Will, Michael D Aleo

J Med Chem· December 2013

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Ligand-protein interactions of selective casein kinase 1δ inhibitors.
Scot Mente, Eric Arnold, Todd Butler, Subramanyam Chakrapani, Ramalakshmi Chandrasekaran, Travis Wager

J Med Chem· September 2013

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Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand.
Lei Zhang, Anabella Villalobos, Elizabeth M Beck, Thomas Bocan, Thomas A Chappie, Travis T Wager

J Med Chem· June 2013

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Getting the MAX out of Computational Models: The Prediction of Unbound-Brain and Unbound-Plasma Maximum Concentrations.
Scot Mente, Angela Doran, Travis T Wager

ACS Med Chem Lett· June 2012

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Strategies to minimize CNS toxicity: in vitro high-throughput assays and computational modeling.
Travis T Wager, Jennifer L Liras, Scot Mente, Patrick Trapa

Expert Opin Drug Metab Toxicol· May 2012

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Csnk1e is a genetic regulator of sensitivity to psychostimulants and opioids.
Camron D Bryant, Clarissa C Parker, Lili Zhou, Christopher Olker, Ramalakshmi Y Chandrasekaran, Travis T Wager

Neuropsychopharmacology· March 2012

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